SB 200646 HYDROCHLORIDE
SB 200646 HYDROCHLORIDE
CAS: 143797-63-1
Molecular Formula: C15H14N4O
SB 200646 HYDROCHLORIDE - Names and Identifiers
| Name | SB 200646 HYDROCHLORIDE |
| Synonyms | SB 200646 SB200646HCl SB 200646 HYDROCHLORIDE N-(1-methyl-5-indolyl)-N'-(3-pyridyl)urea N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea 1-(1-Methyl-1H-indol-5-yl)-3-pyridin-3-yl-urea N-(1-METHYL-1H-INDOL-5-YL)-N'-3-PYRIDINYLUREA HYDROCHLORIDE N-(1-METHYL-1H-5-INDOLYL)-N'-(3-PYRIDINYL)UREA HYDROCHLORIDE |
| CAS | 143797-63-1 |
SB 200646 HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C15H14N4O |
| Molar Mass | 266.3 |
| Solubility | DMSO: ~26 mg/mL, soluble |
| Appearance | solid |
| Color | pale yellow |
| Storage Condition | 2-8°C |
| In vitro study | SB-200646A (4 μM) abolishes the ethanol-induced increase in miniature inhibitory postsynaptic current (mIPSC) frequency and had no effect on basal mIPSC frequency. |
| In vivo study | SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons. The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons. Animal Model: Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment) Dosage: 20 mg/kg Administration: Intravenous injection; daily; for 21 days Result: Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons. |
SB 200646 HYDROCHLORIDE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
SB 200646 HYDROCHLORIDE - Introduction
SB 200646 hydroxychloride is a compound with the formula C20H23N3O2S · HCl, which is a white crystalline solid.
SB200646 HYDROCHLORIDE is widely used in biochemical studies as a selective β3-adrenergic receptor agonist. The compound is used to study diseases such as obesity, diabetes and related metabolic diseases.
The synthesis method of SB 200646 HYDROCHLORIDE is relatively complicated. One possible preparation method is to react SB 200646 with hydrochloric acid and crystallize SB 200646 HYDROCHLORIDE as a crystalline solid under suitable conditions.
It is worth noting that SB 200646 HYDROCHLORIDE is a laboratory compound with certain safety risks. In the use of the process, should follow the relevant laboratory procedures and safe operation guidelines. At the same time, it also needs to be stored in a dry, cool place, and away from fire and upside down.
SB200646 HYDROCHLORIDE is widely used in biochemical studies as a selective β3-adrenergic receptor agonist. The compound is used to study diseases such as obesity, diabetes and related metabolic diseases.
The synthesis method of SB 200646 HYDROCHLORIDE is relatively complicated. One possible preparation method is to react SB 200646 with hydrochloric acid and crystallize SB 200646 HYDROCHLORIDE as a crystalline solid under suitable conditions.
It is worth noting that SB 200646 HYDROCHLORIDE is a laboratory compound with certain safety risks. In the use of the process, should follow the relevant laboratory procedures and safe operation guidelines. At the same time, it also needs to be stored in a dry, cool place, and away from fire and upside down.
Last Update：2024-04-10 22:29:15
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CAS: 143797-63-1
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CAS: 143797-63-1
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View History
SB 200646 HYDROCHLORIDE
橙黄决明素葡萄糖苷
1H-Imidazole, 2-[(4-fluoro-2-nitrophenyl)thio]-
Ccnsmdrd
OCTYL METHYL SULFOXIDE
4-(4-氯-3,5-二甲基-吡唑-1-基甲基)-苯甲酸甲酯
4-氨基-4-四羧水基噻喃
3-亚甲基环丁烷羧酸甲酯
(3,4-二氯苄基)磷酸二乙酯
二乙胺基镓
橙黄决明素葡萄糖苷
1H-Imidazole, 2-[(4-fluoro-2-nitrophenyl)thio]-
Ccnsmdrd
OCTYL METHYL SULFOXIDE
4-(4-氯-3,5-二甲基-吡唑-1-基甲基)-苯甲酸甲酯
4-氨基-4-四羧水基噻喃
3-亚甲基环丁烷羧酸甲酯
(3,4-二氯苄基)磷酸二乙酯
二乙胺基镓